Active microfluidic devices, sensors and implantable devices often require a specific binding property or binding capacity in order to change reactions with an environment or biological fluid The most common systems utilize specific functional groups such as amine, hydroxyl, or carboxyl for conjugation to protein, molecule, integrin, or adhesive component. Gas plasma begins by removing organic surface contaminants by reducing them to volatile compounds. The nascent surface is subsequently reacted to process specific plasma chemistry. Plasmatreat’s advanced plasma chambers, low pressure/batch or atmospheric pressure/inline are versatile tools that are capable of designing controlled interfaces on a variety of materials. This includes streamlining approaches where conventional multi-step wet chemistries are employed. Plasma gives the design engineer the freedom to separate mechanical, optical, and fabrication techniques from the surface requirements. Freedom of choice usually results in significant cost savings. With plasma surface treatment, the choices and capabilities are expansive. Plasma surface treatment is not one process, but an entire chemistry toolbox.